DAVID PEARL: At the age of 18 I was diagnosed with colitis, which is basically an autoimmune disease where your body attacks your own intestines. Initially, it was just the colitis, but they realized that some of the inflammatory process had worked its way into the liver and was attacking my liver. I was diagnosed with an autoimmune disease called sclerosing cholangitis.
MARK POCHAPIN: How old were you at that time?
DAVID PEARL: I was 18 years old.
MARK POCHAPIN: So you were 18 when you were diagnosed with the liver disease or with the colitis?
DAVID PEARL: With the colitis and the liver disease at the same time. Possibly the liver disease a few days later. They had done a liver biopsy and they diagnosed me with the liver disease.
MARK POCHAPIN: Now, the sclerosing cholangitis, as it's called, is a liver disorder. What did they tell you when you had the diagnosis of this?
DAVID PEARL: Actually, they really didn't handle it very well with an 18-year-old. They had told me that they were doing a lot of research and that they didn't know what would happen down the road but that they had hoped that transplant would evolve to give me my life back.
MARK POCHAPIN: So at this point, what year are we talking about, approximately?
DAVID PEARL: This was, I think, in '75, '76.
MARK POCHAPIN: So liver transplantation was really just something that people spoke about but wasn't, in fact, reality at that point.
DAVID PEARL: Right, because they hadn't come up with the magic drugs to ward off the rejection. They were just doing kidney transplants at the time.
MARK POCHAPIN: So what happened to you clinically? What type of symptoms did you develop?